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Updated: Aug 8, 2026

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
10:21

In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus

Published on: December 2, 2012

An unusual intranuclear structure (? viral nucleocapsid) in the brain in subacute sclerosing panencephalitis

A D Dayan, S Majumdar, W Hughes

    Journal of Neurology, Neurosurgery, and Psychiatry
    |February 1, 1974
    PubMed

    Insights

    Measles virus antigens were found inside brain cells of a child with subacute sclerosing panencephalitis. These findings reveal unique viral structures within the brain, aiding in understanding this rare neurological disease.

    Area of Science:

    • Neurology
    • Virology
    • Pathology

    Background:

    • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disease.
    • SSPE is caused by a persistent measles virus infection of the brain.
    • Diagnosis often relies on clinical presentation and laboratory findings.

    Purpose of the Study:

    • To investigate the presence and ultrastructure of measles virus in the brain of a patient with SSPE.
    • To identify specific viral inclusions and structures within affected brain cells.

    Main Methods:

    • Examination of a brain biopsy from a pediatric SSPE patient.
    • Immunofluorescence staining to detect measles viral antigens.
    • Transmission electron microscopy to visualize viral ultrastructure.

    Main Results:

    • Intranuclear deposits of measles viral antigens were identified in parenchymal cells.
    • Electron microscopy revealed viral nucleocapsids within nucleoliform inclusions.
    • Unusual rod-like intranuclear structures, previously only seen in cell cultures, were observed.

    Conclusions:

    • This study confirms the presence of measles virus antigens within the brain tissue of an SSPE patient.
    • The identification of unique viral structures provides insights into the pathogenesis of SSPE.
    • Findings contribute to the understanding of measles virus-induced neurological damage.

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