Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary cholesterol absorption in normal and L-thyroxin-fed rats.

C Lutton, E Brot-Laroche

    Lipids
    |May 1, 1979
    PubMed
    Summary

    Bile cholesterol absorption in rats is higher than dietary cholesterol absorption, primarily occurring in the jejunum. L-thyroxin impacts both biliary and dietary cholesterol absorption.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Low cost polymer intramedullary nails for fracture fixation: a biomechanical study in a porcine femur model.

    Archives of orthopaedic and trauma surgery·2009
    Same author

    Glucose transporter GLUT8 mRNA expression in intestinal Caco-2 cells is regulated by growth and metabolism.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2007
    Same author

    The role of GLUT2 in dietary sugar handling.

    Journal of physiology and biochemistry·2006
    Same author

    Plasma lipids, lipoprotein composition and profile during induction and treatment of hepatic lipidosis in cats and the metabolic effect of one daily meal in healthy cats.

    Journal of animal physiology and animal nutrition·2004
    Same author

    Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice.

    The Journal of physiology·2003
    Same author

    Postprandial variations in the cholesteryl ester transfer protein activity, phospholipid transfer protein activity and plasma cholesterol efflux capacity in normolipidemic men.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2003

    Area of Science:

    • Gastroenterology
    • Cholesterol Metabolism
    • Digestive Physiology

    Background:

    • Cholesterol absorption is a critical physiological process.
    • Understanding the distinct absorption pathways of biliary and dietary cholesterol is essential for metabolic research.

    Purpose of the Study:

    • To investigate the in vivo absorption and movement of biliary cholesterol within the digestive tract.
    • To compare the absorption efficiency of biliary versus dietary cholesterol.
    • To examine the effects of L-thyroxin on cholesterol absorption.

    Main Methods:

    • Infusion of labeled cholesterol in bile into bile fistula rats.
    • Analysis of cholesterol specific activity in micelles and luminal content.
    • Comparison of absorption rates between biliary and dietary cholesterol.
    • Observation of cholesterol absorption in L-thyroxin-fed rats.

    Main Results:

    • Biliary cholesterol absorption (83%) exceeded dietary cholesterol absorption (70%) in rats on a basal diet.
    • Bile cholesterol is predominantly absorbed in the jejunum, while dietary cholesterol absorption occurs throughout the small intestine.
    • Both cholesterol sources preferentially enter villi enterocytes over crypt cells.
    • L-thyroxin administration led to a parallel decrease in both biliary and dietary cholesterol absorption.

    Conclusions:

    • Biliary cholesterol has a distinct and more efficient absorption pathway in the jejunum compared to dietary cholesterol.
    • Increased intestinal transit and jejunal cell renewal in L-thyroxin-treated rats contribute to reduced cholesterol absorption.

    Related Experiment Videos