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Isoxsuprine as an oral vasodilator
Canadian Medical Association Journal
|June 8, 1974
Summary
This study found that oral isoxsuprine did not improve blood flow or claudication time in individuals with or without peripheral vascular disease. The drug showed no significant effect on blood pressure or heart rate, questioning its value as a vasodilator.
Area of Science:
- Pharmacology
- Vascular Medicine
- Clinical Trials
Background:
- Peripheral vascular disease (PVD) affects circulation.
- Isoxsuprine is a vasodilator drug.
- Oral administration efficacy for PVD is debated.
Purpose of the Study:
- To evaluate the efficacy of oral isoxsuprine.
- To assess isoxsuprine's effect on peripheral blood flow.
- To determine if isoxsuprine improves claudication time.
Main Methods:
- Double-blind, placebo-controlled crossover study.
- 12 volunteers with PVD and 12 without.
- Oral 20-mg isoxsuprine tablet administration.
Main Results:
- Isoxsuprine did not increase calf, foot, or hand blood flow.
- No significant changes in blood pressure or heart rate observed.
- Claudication time was not improved by isoxsuprine.
Conclusions:
- Oral isoxsuprine is ineffective as a peripheral vasodilator.
- The study does not support isoxsuprine's use for PVD.
- Further research may be needed for alternative formulations or indications.