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Published on: June 11, 2009
The small-intestinal mucosa in cow's milk allergy
Lancet (London, England)
|January 18, 1975
Summary
Cow's milk allergy in infants involves intestinal immune reactions, including increased IgE plasma-cells and mast cell degranulation. These findings support diagnosis and treatment with disodium cromoglycate for cow
Area of Science:
- Immunology
- Pediatric Gastroenterology
- Allergy Research
Background:
- Cow's milk protein allergy is a common concern in infants.
- Understanding the localized immune responses in the small intestine is crucial for diagnosis.
Purpose of the Study:
- To investigate the local immune reactions in the small intestine of infants with suspected cow's milk protein allergy.
- To explore the potential of disodium cromoglycate in managing such allergies.
Main Methods:
- Analysis of small intestinal biopsies from infants after cow's milk ingestion.
- Assessment of mucosal IgE plasma cells, mast cell degranulation, IgM plasma cells, and complement C3 deposition.
Main Results:
- Infants showed increased mucosal IgE plasma cells and mast cell degranulation, indicating a local reaginic reaction.
- Elevated IgM plasma cells and deposition of IgG and C3 complement were observed, suggesting multiple immune pathways.
Conclusions:
- The study demonstrates simultaneous immune reactions in the intestinal mucosa of infants with cow's milk allergy.
- Findings support the use of these immunological markers for diagnosing cow's milk allergy.
- Disodium cromoglycate shows potential as a treatment for similar cases.
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