Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Afferent fibers in the ventral root.

R E Coggeshall

    Neurosurgery
    |May 1, 1979
    PubMed
    Summary

    Dorsal rhizotomy for chronic pain has limited success. New findings suggest ventral root afferent fibers may explain failures, proposing dorsal root ganglionectomy as a potentially more effective treatment for intractable pain.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A morphological and functional study on a cluster of identifiable neurosecretory cells in the abdominal ganglion of aplysia californica.

    The Journal of cell biology·2009
    Same author

    Human neural stem cell-derived cholinergic neurons innervate muscle in motoneuron deficient adult rats.

    Neuroscience·2005
    Same author

    A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.

    Neuroscience·2003
    Same author

    N-methyl-D-aspartate-induced excitation and sensitization of normal and inflamed nociceptors.

    Neuroscience·2003
    Same author

    Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat.

    Neuroscience·2001
    Same author

    Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization.

    Neuroscience letters·2001

    Area of Science:

    • Neurosurgery
    • Pain Management
    • Spinal Cord Anatomy

    Background:

    • Dorsal rhizotomy, an early surgical treatment for chronic pain, relies on the principle of distinct sensory (dorsal) and motor (ventral) nerve roots.
    • This procedure aims to eliminate pain by severing dorsal roots, but often yields low success rates with pain recurrence.

    Purpose of the Study:

    • To review existing and new research on ventral root afferent fibers.
    • To explore the potential role of these fibers in the failure of dorsal rhizotomy for chronic pain.
    • To discuss the clinical implications of ventral root afferent fibers, particularly regarding alternative surgical approaches.

    Main Methods:

    • Literature review of studies on ventral root afferent fibers.
    • Analysis of the anatomical separation of spinal root functions.
    • Comparison of dorsal rhizotomy and dorsal root ganglionectomy efficacy.

    Main Results:

    • Recent discoveries indicate a significant presence of ventral root afferent fibers.
    • These fibers challenge the traditional understanding of spinal root function.
    • Ventral root afferents are likely present in humans and may contribute to dorsal rhizotomy's failure.

    Conclusions:

    • The law of separation of spinal root function may be inaccurate due to ventral root afferents.
    • Dorsal rhizotomy may be insufficient for chronic pain relief if ventral root afferents are involved.
    • Dorsal root ganglionectomy, removing both dorsal and ventral afferents, could offer a more effective treatment for intractable pain.

    Related Experiment Videos