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External and internal effects of tetraethylammonium on voltage-dependent and Ca-dependent K+ currents components in
Neuroscience Letters
|April 1, 1979
Abstract:
Ca-dependent and voltage-dependent K+ currents in Aplysia pacemaker neurons were studied separately by electrophoretic injections of Ca2+ ions into the cells to induce the Ca-dependent component and by step depolarizations in the absence of external Ca2+ ions to induce the voltage-dependent component. Intracellular tetraethylammonium (TEA) blocks the voltage-dependent but not the Ca-dependent K+ current. Extracellular TEA blocks both components reversibly but is more effective in inhibiting the Ca-dependent K+ currents. Our results suggest that there are TEA receptor sites for the voltage-dependent K+ current on each side of the membrane, but only an external receptor site for the Ca-dependent K+ current.