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Treatment of Bacteroides infection with clindamycin-2-phosphate

P C Dickinson, P Saphyakhajon

    Canadian Medical Association Journal
    |November 2, 1974
    PubMed

    Insights

    Systemic clindamycin-2-phosphate effectively treated serious Bacteroides infections in eighteen patients. Sixteen patients recovered fully, confirming the drug's clinical usefulness for these challenging infections.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Clinical Medicine

    Background:

    • Bacteroides species are significant pathogens in serious intra-abdominal and gynecological infections.
    • Effective antimicrobial therapy is crucial for managing severe Bacteroides infections.
    • Clindamycin-2-phosphate is a potential treatment option for these infections.

    Purpose of the Study:

    • To evaluate the clinical efficacy and safety of systemic clindamycin-2-phosphate in patients with serious Bacteroides infections.
    • To assess the range of infections successfully treated with clindamycin-2-phosphate.

    Main Methods:

    • A cohort of eighteen patients with serious Bacteroides infections was treated with systemic clindamycin-2-phosphate.
    • Patient outcomes, including recovery and complications, were monitored.
    • Adverse events associated with clindamycin-2-phosphate were recorded.

    Main Results:

    • Sixteen out of eighteen patients recovered without complications.
    • Two patients treated with clindamycin-2-phosphate died.
    • Few side effects were observed during the treatment period.
    • Successful treatment was observed across various infections, including septic abortion, posthysterectomy infections, pelvic inflammatory disease, bowel perforation, and pancreatic abscess.

    Conclusions:

    • Systemic clindamycin-2-phosphate demonstrates significant clinical usefulness in treating serious Bacteroides infections.
    • The drug is well-tolerated with a low incidence of side effects.
    • Clindamycin-2-phosphate is a viable therapeutic option for a spectrum of severe infections caused by Bacteroides species.

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