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Immunological responses to Candida albicans II. Amyloidosis in mice induced by candidiasis
Infection and Immunity
|December 1, 1974
Abstract:
Candida albicans infection in the mouse thigh rapidly induces amyloidosis in mice of the C57BL/Ks strain; amyloid is induced more slowly and to a lesser extent by viable candida in C3H and AKR mice, and by both viable Saccharomyces cerevisiae and heat-killed C. albicans in C57BL/Ks mice.
Insights
Candida albicans infection rapidly causes amyloidosis in C57BL/Ks mice. Other mouse strains and yeast species show slower or lesser amyloid induction, indicating strain- and species-specific responses to fungal infections.
Area of Science:
- Microbiology and Immunology
- Pathology
- Host-Pathogen Interactions
Background:
- Fungal infections, particularly Candida albicans, can trigger host immune responses.
- Amyloidosis, the abnormal accumulation of proteins, can be influenced by inflammatory processes.
- Understanding host responses to fungal pathogens is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the induction of amyloidosis by Candida albicans infection in different mouse strains.
- To compare the amyloidogenic potential of viable and heat-killed Candida albicans.
- To assess the amyloid-inducing capacity of Saccharomyces cerevisiae.
Main Methods:
- Induction of infection in mouse thigh models using viable Candida albicans.
- Inoculation with viable Saccharomyces cerevisiae and heat-killed Candida albicans.
- Assessment of amyloid deposition in different mouse strains (C57BL/Ks, C3H, AKR).
Main Results:
- Rapid and significant amyloidosis was observed in C57BL/Ks mice infected with Candida albicans.
- Slower and less pronounced amyloid induction occurred in C3H and AKR mice.
- Both viable Saccharomyces cerevisiae and heat-killed Candida albicans induced amyloidosis in C57BL/Ks mice, though the kinetics and extent may differ.
Conclusions:
- Candida albicans infection is a potent inducer of amyloidosis in susceptible mouse strains.
- Host genetic background significantly influences the development of infection-induced amyloidosis.
- Different fungal species and forms (viable vs. heat-killed) can elicit amyloidogenic responses, highlighting the complexity of host-fungal interactions.