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Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages

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Effects of corticosteroids on human monocyte function.

J J Rinehart, S P Balcerzak, A L Sagone

The Journal of Clinical Investigation

|December 1, 1974

Summary

This summary is machine-generated.

Corticosteroids like hydrocortisone succinate impair human monocyte immune functions, including chemotaxis and bactericidal activity. These effects may reduce cellular defense during corticosteroid treatment.

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Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

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Area of Science:

Immunology
Pharmacology

Background:

Monocytes are crucial for immune and nonimmune cellular defense.
Corticosteroids are widely used and can impact immune cell function.

Purpose of the Study:

To investigate the in vitro effects of corticosteroids on human peripheral blood monocyte functions.
To determine if specific corticosteroid formulations differentially affect monocyte activity.

Main Methods:

Human peripheral blood monocytes were exposed to various corticosteroids (hydrocortisone succinate, methylprednisolone succinate, hydrocortisone phosphate, cortisone acetate).
Monocyte chemotaxis, random migration, bactericidal activity, phagocytosis, and adherence were assessed.
Granulocyte functions were also evaluated for comparison.

Main Results:

Hydrocortisone succinate (HCS) significantly reduced monocyte chemotaxis and random migration at 16 µg/ml.
HCS impaired monocyte bactericidal activity but not phagocytosis at higher concentrations.
Granulocyte chemotaxis was unaffected by HCS, but bactericidal activity was reduced.

Conclusions:

Corticosteroids, particularly HCS, can induce defects in critical monocyte functions.
These drug-induced impairments may compromise host defense mechanisms during corticosteroid therapy.