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Related Experiment Videos

The human enteric coronaviruses.

S K Clarke, E O Caul, S I Egglestone

    Postgraduate Medical Journal
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Coronaviruses were detected in adult and child fecal samples, though not definitively linked to gastroenteritis outbreaks. Prolonged virus shedding was observed, with limited success in laboratory propagation.

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    Area of Science:

    • Virology
    • Gastroenterology
    • Public Health

    Background:

    • Coronaviruses are known human pathogens.
    • Gastroenteritis is a common illness affecting various age groups.
    • The role of coronaviruses in gastroenteritis outbreaks requires further investigation.

    Purpose of the Study:

    • To investigate the prevalence of coronavirus in fecal samples from individuals with and without diarrhea or gastroenteritis.
    • To assess the potential association between coronavirus detection and gastroenteritis outbreaks.
    • To study the shedding patterns and in vitro propagation of detected coronavirus strains.

    Main Methods:

    • Fecal samples were collected from adults with and without diarrhea, and from children and infants with gastroenteritis.
    • Samples were analyzed for the presence of coronavirus using electron microscopy.

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  • Attempts were made to propagate one coronavirus strain in human cell cultures and organ cultures.

    • Main Results:

    • Coronaviruses were detected in 15.0% of adults with diarrhea and 5.2% of adults without diarrhea.
    • Coronaviruses were found in 2.2% of children (1-14 years) with gastroenteritis but not in infants (<1 year).
    • No definitive link was established between coronavirus and 34 gastroenteritis outbreaks; however, it may have caused diarrhea in a psycho-geriatric unit. Prolonged virus excretion was noted, and serial passage in culture was unsuccessful.

    Conclusions:

    • Coronaviruses are present in fecal samples of individuals with and without gastrointestinal symptoms.
    • While not a primary cause of widespread gastroenteritis outbreaks in this study, coronaviruses may contribute to diarrhea in specific populations.
    • Further research is needed to understand the clinical significance and transmission dynamics of coronaviruses in gastrointestinal illnesses.