Related Experiment Video
Updated: Aug 9, 2026

09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Summary
Anesthesia-associated deaths are a significant public health issue, with an estimated 5,000 annual fatalities in the U.S. Improved methods are needed to track these preventable deaths and reduce anesthesia risks.
Area of Science:
- Medical Science
- Public Health
- Anesthesiology
Background:
- Anesthesia-associated deaths have occurred since the advent of surgical anesthesia in 1846.
- Current methods for identifying anesthesia-related fatalities are insufficient, leading to underreporting.
- Existing data sources, such as the National Center for Health Statistics and medical literature, capture only a fraction of total incidents.
Purpose of the Study:
- To estimate the annual number of anesthesia-associated deaths in the United States.
- To highlight anesthesia as a public health problem requiring attention.
- To compare anesthesia-related mortality with other diseases.
Main Methods:
- Extrapolation of data from community anesthesia study committees.
- Analysis of population and operative figures to estimate incidence.
- Comparison with mortality statistics for other diseases.
Main Results:
- An estimated 5,000 deaths are associated with anesthesia annually in the U.S.
- Anesthesia-related deaths significantly outnumber those from diseases like muscular dystrophy, multiple sclerosis, sickle cell anemia, myasthenia gravis, and poliomyelitis.
- The true number of anesthesia mishaps is likely higher than currently reported.
Conclusions:
- Anesthesia is an iatrogenic disease that poses a serious public health concern.
- There is a critical need for improved surveillance and reporting of anesthesia-associated deaths.
- Recognizing anesthesia risks is essential for patient safety and public health initiatives.
Related Concept Videos
Local Anesthetics: Pharmacokinetics
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
General Anesthesia: Overview
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Parenteral Anesthetics: Overview
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inhalational Anesthetics: Overview
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...

