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Defective growth hormone secretion in primary microcephaly.

C Dacou-Voutetakis, T Karpathios, N Logothetis

    The Journal of Pediatrics
    |October 1, 1974
    PubMed
    Summary
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    Growth hormone (GH) deficiency and lack of secretory episodes were found in some microcephalic children. This pituitary hypofunction may contribute to impaired growth and be linked to cerebral abnormalities.

    Area of Science:

    • Pediatric Endocrinology
    • Neuroendocrinology
    • Genetics

    Background:

    • Microcephaly is a condition characterized by a smaller head circumference than normal.
    • Growth hormone (GH) plays a crucial role in childhood development and growth.
    • Disorders of GH secretion can lead to significant growth impairment.

    Purpose of the Study:

    • To investigate the 24-hour variations of plasma growth hormone (GH) and GH secretion in microcephalic children.
    • To determine if GH deficiency or impaired GH secretion is present in these children.
    • To explore potential associations between cerebral abnormalities and pituitary hypofunction in microcephaly.

    Main Methods:

    • Studied five microcephalic children.
    • Measured 24-hour plasma growth hormone (GH) levels.

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  • Assessed GH secretion in response to oral glucose load and insulin-induced hypoglycemia.

    • Main Results:

    • Three of the five children exhibited low GH levels.
    • Two of these three children, who were brothers, showed a complete lack of GH secretory episodes.
    • GH deficiency was identified as a potential principal or contributing factor to impaired growth in some cases.

    Conclusions:

    • GH deficiency and impaired GH secretion may be associated with microcephaly.
    • A potential link between cerebral abnormalities and pituitary hypofunction is suggested.
    • The findings suggest parallels with neuroendocrine syndromes like Kallmann's and de Morsier's.