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Modification by drugs of the secretagogue effect of dopamine on the pancrease.

Y Furuta, K Hashimoto, Y Ishii

    British Journal of Pharmacology
    |June 1, 1974
    PubMed
    Summary
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    Dopamine and L-DOPA stimulate exocrine pancreatic secretion by interacting with specific receptors. Dopamine has a physiological role in the pancreas independent of noradrenaline.

    Area of Science:

    • Neuroendocrinology
    • Gastroenterology

    Background:

    • The roles of dopamine and its precursor L-DOPA in regulating exocrine pancreatic secretion are not fully understood.
    • Investigating these roles can elucidate novel mechanisms of pancreatic function.

    Purpose of the Study:

    • To investigate the specific stimulating actions of dopamine and L-DOPA on exocrine pancreatic secretion.
    • To explore the interaction of dopamine with pancreatic receptors and its physiological significance.

    Main Methods:

    • Experiments were conducted on an isolated blood-perfused canine pancreas model.
    • Various catecholamines and related compounds were administered intra-arterially to assess their effects on pancreatic secretion.
    • Noradrenaline and dopamine content in pancreatic tissue was quantified using biochemical assays.

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    Main Results:

    • Dopamine and L-DOPA were found to stimulate exocrine pancreatic secretion.
    • Alpha-methyldopa inhibited the L-DOPA-induced secretion, suggesting L-DOPA conversion to dopamine.
    • Apomorphine partially blocked dopamine-induced secretion, indicating specific receptor involvement.
    • Pancreatic dopamine levels increased following L-DOPA or secretin administration, while noradrenaline levels remained unaffected.
    • Reserpine decreased noradrenaline but not dopamine content.

    Conclusions:

    • L-DOPA likely stimulates the exocrine pancreas after conversion to dopamine.
    • Dopamine appears to interact with specific receptors to modulate pancreatic secretion.
    • Dopamine possesses a physiological function within the pancreas that is distinct from noradrenaline's role.