[Prilocaine as an hypotensive ocular agent (author's transl)]

The purpose of the present investigation was to determine the action of prilocaine as hypotensive ocular agent. Prilocaine in doses of 2.5 mg/kg, 5 mg/kg and 10 mg/kg was administered intravenously in dogs anesthetized with sodium pentobarbital (30 mg/kg). The experiments show that prilocaine when used i.v. in doses of 2.5 mg/kg and 5 mg/kg causes ocular hypotension in dogs, whereas doses of 10 mg/kg i.v. produce this effect only when artificial respiration is employed, thus preventing the increase of the pCO2 in the blood.