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Related Experiment Videos

Corneal arcus and hyperlipoproteinaemia.

B M Rifkind

    Survey of Ophthalmology
    |March 1, 1972
    PubMed
    Summary

    Corneal arcus, a lipid deposit in the eye, is linked to high cholesterol and phospholipid levels. Its occurrence, especially premature, indicates potential familial hyperlipoproteinemia, such as Type II and III.

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    Area of Science:

    • Ophthalmology
    • Genetics
    • Lipidology

    Background:

    • Corneal arcus is a common lipid deposition in the eye, primarily composed of cholesterol and phospholipids.
    • Its prevalence is influenced by age, sex, and ethnicity, and it has been historically associated with plasma lipid levels and familial hyperlipidemias.

    Purpose of the Study:

    • To explore the association between corneal arcus and lipid metabolism disorders.
    • To understand the link between premature corneal arcus and specific types of familial hyperlipoproteinemia.

    Main Methods:

    • Literature review of studies on corneal arcus and lipid disorders.
    • Analysis of recent classifications of hyperlipoproteinemia and their relation to corneal arcus.

    Main Results:

    • Corneal arcus consists mainly of cholesterol and phospholipids.
    • Premature corneal arcus is linked to familial Type II and Type III hyperlipoproteinemia.
    • Other rare lipid disorders like Tangier Disease and lecithin:cholesterol acyl transferase deficiency can also cause corneal opacities.

    Conclusions:

    • Corneal arcus serves as a potential indicator for underlying lipid metabolism abnormalities.
    • Early detection of corneal arcus may warrant investigation for familial hyperlipoproteinemia.

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