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Dynamics of skeletal pattern formation in developing chick limb.

S A Newman, H L Frisch

    Science (New York, N.Y.)
    |August 17, 1979
    PubMed
    Summary
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    Embryonic limb development relies on fibronectin patterns forming in the extracellular matrix. These molecular patterns guide cartilage formation and skeletal element arrangement during chick limb development.

    Area of Science:

    • Developmental Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • Limb skeletal pattern formation involves sequential emergence of cartilaginous primordia.
    • Changes in cellular contacts precede cartilage differentiation in precartilage mesenchyme.
    • Extracellular matrix molecules play a crucial role in developmental patterning.

    Purpose of the Study:

    • To investigate the role of cell surface proteins, like fibronectin, in patterning embryonic limb development.
    • To understand how molecular diffusion and cellular changes influence skeletal element formation.
    • To explore the relationship between morphogen patterns and the proximodistal sequence of skeletal elements.

    Main Methods:

    • Modeling the biosynthesis and diffusion of fibronectin in the extracellular matrix.

    Related Experiment Videos

  • Analyzing spatial patterns of fibronectin under simulated cellular differentiation.
  • Investigating the effect of changing mesenchymal diffusion chamber size on morphogen patterns.

    • Main Results:

    • Fibronectin biosynthesis and diffusion can generate spatial patterns in the extracellular matrix.
    • Reduced mesenchymal diffusion chamber size leads to sequential morphogen pattern reorganization.
    • These patterns correlate with the observed proximodistal emergence of skeletal elements.

    Conclusions:

    • Spatial patterns of fibronectin can serve as a basis for emergent cartilaginous primordia.
    • Sequential reorganization of morphogen patterns, driven by cellular changes, underlies skeletal element row formation.
    • Maintenance of a boundary condition at the limb bud apex is critical for skeletal element emergence.