Related Experiment Video
Updated: May 5, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
18.5K
Functional evaluation of prolactin secretion: a guide to therapy
The Journal of Clinical Investigation
|March 1, 1972
Summary
This study explores methods to evaluate prolactin secretion using stimulation and inhibition tests. Thyrotropin-releasing hormone (TRH) and chlorpromazine increase secretion, while L-Dopa decreases it, potentially treating galactorrhea.
Area of Science:
- Endocrinology
- Neuroendocrinology
Background:
- Prolactin secretion is regulated by complex hormonal feedback mechanisms.
- Understanding these regulatory pathways is crucial for diagnosing and treating endocrine disorders.
Purpose of the Study:
- To propose and evaluate stimulation and inhibition tests for assessing prolactin secretion.
- To investigate the effects of specific agents on prolactin release.
Main Methods:
- Utilizing thyrotropin-releasing hormone (TRH) as a stimulatory agent for prolactin release.
- Employing chlorpromazine to investigate its effects on prolactin secretion, potentially at the hypothalamic level.
- Administering L-Dopa (D,L-alpha-hydrazino-alpha-methyl-beta-[3,4-di-hydroxyphenyl]) to assess its inhibitory impact on prolactin secretion.
Main Results:
- Thyrotropin-releasing hormone (TRH) effectively stimulates prolactin release from the pituitary gland.
- Chlorpromazine demonstrated an increase in prolactin secretion, likely mediated by hypothalamic actions.
- L-Dopa exhibited an inhibitory effect on prolactin secretion.
Conclusions:
- TRH and chlorpromazine serve as effective agents for stimulating prolactin secretion.
- L-Dopa shows potential as an inhibitor of prolactin secretion and for managing conditions like galactorrhea.
Related Concept Videos
01:01Feedback Loops
43.9K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
43.9K
01:15Nursing Evaluation
4.1K
The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.
4.1K
01:19Regulation of Hormone Secretion
6.5K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
6.5K
01:27Hormones of the Pituitary Gland
14.2K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
14.2K
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271