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Updated: Aug 11, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
Published on: October 27, 2009
Direct measurement of the amount of bound collagen which stimulates platelet aggregation
Abstract:
The amount of collagen which binds to platelets has been correlated with aggregating activity in a platelet aggregometer. Aggregating activity requires only 0.22 microgram/ml (0.35 microgram/10(9) cells) of collagen bound, the reaction saturating with 4.9 microgram/ml (7.9 microgram/10(9) cells). On the basis of the fraction of collagen bound and its hydroxyproline/proline ratio, it is concluded that the activity resides in the type I collagen component.
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