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Related Experiment Videos

A virus from epidemic vomiting disease.

S K Clarke, G T Cook, S I Egglestone

    British Medical Journal
    |July 8, 1972
    PubMed
    Summary

    A novel gastrointestinal illness characterized by vomiting and fever was identified. The causative agent, a non-bacterial, non-viral pathogen, is ether-stable and filters through a 50-nm pore size.

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    Area of Science:

    • Gastroenterology
    • Virology
    • Infectious Diseases

    Background:

    • An unexplained illness with vomiting, fever, and mild diarrhea occurred in a boarding school.
    • The illness had a short incubation period, suggesting a rapidly acting infectious agent.

    Purpose of the Study:

    • To identify the causative agent of the observed gastrointestinal illness.
    • To characterize the properties of the infectious agent responsible for the outbreak.

    Main Methods:

    • Filtered fecal extracts from affected individuals were administered to volunteers.
    • Standard microbiological techniques, including bacterial culture and virus detection in tissue/organ cultures, were employed.
    • The agent's physical and chemical properties, such as ether stability and filterability, were assessed.

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    Main Results:

    • The illness was successfully reproduced in volunteers, with vomiting as the primary diagnostic symptom.
    • No pathogenic bacteria or detectable viruses were found in the affected individuals' feces.
    • The infectious agent passed through a 50-nm filter and was stable in ether, indicating it is likely a non-enveloped virus or a small pathogenic molecule.

    Conclusions:

    • The study identified an infectious agent responsible for a distinct gastrointestinal illness.
    • The agent's characteristics suggest it is a novel pathogen, potentially a small virus or prion, not detectable by standard diagnostic methods.
    • Further research is warranted to fully elucidate the nature and transmission of this ether-stable, filterable agent.