[Effect of detergents on pancreatic ribonuclease]

It is established that the activity of pancreatic ribonuclease does not change under the effect of nonionic and some ionic detergents within a concentration range of 0.5-5.0 mg/ml and decreases in the presence of DS-Na and cetavlon (1.0 and 2.5 mg/ml, respectively). Studies on kinetics of ribonuclease thermoinactivation in the presence of different detergents showed a stabilizing effect of cetavlon and DS-Na in a concentration of 1 mg/ml.