Bovine nasal granuloma. Gross and microscopic lesions

The anterior nasal mucosa of 21 cattle had small closely-packed polypoid nodules. These had a distribution pattern similar to that of inhaled particles. Acute inflammatory changes consisting of eosinophil infiltration, mast cell and globule leucocyte hyperplasia, and oedema were frequent in the epithelium, terminal gland ducts and adjacent lamina propria. Epithelium over nodules was metaplastic to non-keratinising stratified squamous, whilst epithelium of terminal gland ducts was metaplastic to mucus-secreting pseudostratified columnar. Focal accumulation of granulation tissue between gland ducts caused herniations of the superficial lamina propria to form the nodules.