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Experimental visceral aspergillosis.

H Sidransky, S M Epstein, E Verney

The American Journal of Pathology

|October 1, 1972

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Germinating Aspergillus flavus spores cause lethal infections in mice, overwhelming immune defenses. Non-germinating spores are cleared by phagocytic cells, preventing invasive aspergillosis.

Area of Science:

Mycology
Immunology
Pathogenesis

Background:

Experimental aspergillosis pathogenesis is not fully understood.
Immune suppression can increase susceptibility to fungal infections.

Purpose of the Study:

To investigate the role of Aspergillus flavus spore germination in the development of invasive aspergillosis.
To determine the efficacy of phagocytic cells in clearing fungal spores.

Main Methods:

Mice were pretreated with cortisone acetate or thioglycollate to modulate immune responses.
Intraperitoneal injection of germinating and non-germinating Aspergillus flavus spores.
Observation of infection incidence, dissemination, and mortality.

Main Results:

Related Experiment Videos

Cortisone acetate-treated mice developed lethal visceral hyphal aspergillosis after infection with non-germinating spores.
Germinating Aspergillus flavus spores induced a high incidence of fatal disease in normal mice.
Phagocytic cells cleared non-germinating spores but failed to control early germinating spores.

Conclusions:

Spore germination is critical for the development of disseminated hyphal aspergillosis.
Early germinating spores evade phagocytic clearance, leading to invasive disease.
Immune status significantly impacts the outcome of Aspergillus flavus infection.