[Ultrastructural changes in the liver of rats with a Yoshida tumor under exposure to cyclophosphamide]

Sixteen Wistar line rats with Joshida tumor were given cyclophosphamide either daily or with two-day intervals. The changes observed were mostly those related with the Golgi complex apparatus, lysosomes, biliary canaliculi as well as hyaloplasma. The degree of pronouncement of these changes was dependent on the duration of cyclophosphamide administration. The ultrastructure of biliary canaliculi changed according to the type, observed in intrahepatic cholestasis, makes it mandatory to be careful while using cyclophosphamide in patients with the cholestatic syndrome.