The significance of histological changes in serial prostatic biopsy specimens

Study of the histological appearance of randomly chosen areas of hyperplastic prostatic glands revealed that such areas are highly variable in appearance. Any such area of the size comparable to biopsy specimens does not give a representative picture of the entire gland. It is not possible from the appearance of single, serial biopsy specmens to draw any conclusions on the effect of hormonal treatment of the hyperplastic prostrate.