Characterization of the subunits of thymidylate synthetase

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Effects and mechanisms of Stauntonia brachyanthera Hand.-Mazz against Alzheimer's disease through network pharmacology and experimental validation.

Biochemical and biophysical research communications·2026

SIRT6 restrains hyperactivated Nrf2 to enhance cisplatin response in lung cancer models.

Biochemical and biophysical research communications·2026

Differential aggregation and seeding of tau microtubule-binding region fragments in vitro.

Biochemical and biophysical research communications·2026

Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling.

Biochemical and biophysical research communications·2026

PIEZO1 promotes YAP/TEAD-dependent profibrotic signaling in POSTN-enriched lung fibroblast activation.

Biochemical and biophysical research communications·2026

Crystal structure and glycan-binding ability of galectin domain of OsGALT1.

Biochemical and biophysical research communications·2026

Liver disease reveals KIF12 as a regulator of mitochondria, lysosome and cilia localisation in human cholangiocytes.

EBioMedicine·2026

Transgenerational chromosome repair in the asexual bdelloid rotifer Adineta vaga.

Science advances·2026

Site-Specific Measurement of Meiotic Crossing-Over Rate with Droplet Digital PCR.

Cold Spring Harbor protocols·2026

The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis.

Nature cell biology·2026

Whole-genome sequencing identifies a c.1282C > T missense variant in Taurine Transporter (TauT) associated with taurine-mediated dilated cardiomyopathy in a family of domestic shorthair cats.

Journal of molecular and cellular cardiology·2026

Mitochondrial genome characteristics and phylogenetic analysis of Ramaria longispora.

Mitochondrial DNA. Part B, Resources·2026

Related Experiment Videos

Characterization of the subunits of thymidylate synthetase

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Effects and mechanisms of Stauntonia brachyanthera Hand.-Mazz against Alzheimer's disease through network pharmacology and experimental validation.

SIRT6 restrains hyperactivated Nrf2 to enhance cisplatin response in lung cancer models.

Differential aggregation and seeding of tau microtubule-binding region fragments in vitro.

Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling.

PIEZO1 promotes YAP/TEAD-dependent profibrotic signaling in POSTN-enriched lung fibroblast activation.

Crystal structure and glycan-binding ability of galectin domain of OsGALT1.

Liver disease reveals KIF12 as a regulator of mitochondria, lysosome and cilia localisation in human cholangiocytes.

Transgenerational chromosome repair in the asexual bdelloid rotifer Adineta vaga.

Site-Specific Measurement of Meiotic Crossing-Over Rate with Droplet Digital PCR.

The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis.

Whole-genome sequencing identifies a c.1282C > T missense variant in Taurine Transporter (TauT) associated with taurine-mediated dilated cardiomyopathy in a family of domestic shorthair cats.

Mitochondrial genome characteristics and phylogenetic analysis of Ramaria longispora.

Related Experiment Videos

Characterization of the subunits of thymidylate synthetase

Related Concept Videos

Related Articles