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Increased production of endogenous pyrogen and lysozyme by blood monocytes in sarcoidosis

P T Bodel, P T Major, J B Gee

    The Yale Journal of Biology and Medicine
    |May 1, 1979
    PubMed

    Insights

    Monocytes from sarcoidosis patients secrete more fever-mediating endogenous pyrogen (EP) and lysozyme (L) than normal individuals. This suggests increased inflammatory potential in these immune cells before disease localization.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Sarcoidosis is an inflammatory disease characterized by granuloma formation.
    • The role of circulating monocytes in sarcoidosis pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the in vitro secretory capacity of monocytes from sarcoidosis patients.
    • To assess the secretion of endogenous pyrogen (EP) and lysozyme (L) by these cells.

    Main Methods:

    • Blood monocytes were isolated from patients with sarcoidosis and healthy controls.
    • Cells were incubated with endotoxin to stimulate secretion.
    • Secretion levels of EP and L were measured over time.

    Main Results:

    • Monocytes from sarcoidosis patients released twice as much EP compared to controls after endotoxin stimulation.
    • Elevated lysozyme (L) secretion was observed in monocytes from a subset of sarcoidosis patients.
    • Increased L secretion persisted for 3 days and correlated with serum L levels.

    Conclusions:

    • Circulating monocytes in some sarcoidosis patients exhibit an enhanced capacity for EP and L secretion.
    • This heightened secretory function may contribute to the inflammatory processes in sarcoidosis prior to tissue localization.

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