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Related Experiment Videos

Neuropathy, M components, and amyloid.

M D Benson, A S Cohen, K D Brandt

    Lancet (London, England)
    |January 4, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Peripheral neuropathy is a notable early sign in some systemic amyloidosis patients. This neurological complication, particularly median nerve issues, often precedes other amyloidosis symptoms and is linked to monoclonal gammopathies.

    Area of Science:

    • Neurology
    • Rheumatology
    • Oncology

    Background:

    • Systemic amyloidosis is a rare disease characterized by amyloid protein deposition in organs.
    • Neurological involvement, specifically peripheral neuropathy, can occur in systemic amyloidosis.
    • The relationship between neuropathy and specific types of amyloidosis, especially those with monoclonal gammopathies, requires further elucidation.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of peripheral neuropathy in patients with nonhereditary systemic amyloidosis.
    • To determine if neurological manifestations precede other clinical evidence of amyloidosis.
    • To explore the association between peripheral neuropathy and monoclonal gammopathies in systemic amyloidosis.

    Main Methods:

    • Retrospective analysis of 87 patients with nonhereditary systemic amyloidosis.

    Related Experiment Videos

  • Clinical assessment for peripheral neuropathy, including median-nerve neuropathy and sensorimotor neuropathy.
  • Review of medical records for evidence of monoclonal gammopathy (serum M-component or Bence-Jones proteinuria) and other systemic amyloidosis manifestations.
  • Nerve biopsy in select cases to confirm amyloid deposition.

    • Main Results:

    • Ten out of 87 patients (11.5%) had peripheral neuropathy.
    • Median-nerve neuropathy was observed in six patients due to flexor retinaculum infiltration.
    • Neuropathy preceded other amyloidosis signs by 6 months to 4 years (mean 1-5 years).
    • Neuropathy occurred in 6/38 primary amyloidosis and 4/14 amyloidosis with B-cell dyscrasias patients, all with monoclonal gammopathy.
    • No neuropathy was observed in 56 patients without monoclonal gammopathy.

    Conclusions:

    • Peripheral neuropathy is a significant neurological manifestation in nonhereditary systemic amyloidosis.
    • Neuropathy, particularly median nerve involvement, can be an early presenting symptom.
    • The presence of monoclonal gammopathy is strongly associated with the development of neuropathy in systemic amyloidosis.