Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The morphopathologic substrates of concussion?

J T Povlishock, D P Becker, J D Miller

    Acta Neuropathologica
    |June 15, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Delayed increase in extracellular glycerol with post-traumatic electrographic epileptic activity: support for the theory that seizures induce secondary injury.

    Acta neurochirurgica. Supplement·2002
    Same author

    alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.

    Bioorganic & medicinal chemistry letters·2001
    Same author

    alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.

    Bioorganic & medicinal chemistry letters·2001
    Same author

    Advances in management of neurosurgical trauma: USA and Canada.

    World journal of surgery·2001
    Same author

    Selective, orally active MMP inhibitors with an aryl backbone.

    Bioorganic & medicinal chemistry letters·2001
    Same author

    Metabolic recovery following human traumatic brain injury based on FDG-PET: time course and relationship to neurological disability.

    The Journal of head trauma rehabilitation·2001
    Same journal

    Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

    Acta neuropathologica·2026
    Same journal

    Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes.

    Acta neuropathologica·2026
    Same journal

    Prion-like transmission and propagation of human β-amyloid to the bank vole rodent model.

    Acta neuropathologica·2026
    Same journal

    Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.

    Acta neuropathologica·2026
    Same journal

    VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy.

    Acta neuropathologica·2026
    Same journal

    Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis.

    Acta neuropathologica·2026
    See all related articles

    Concussive brain injury causes neurons to uptake horseradish peroxidase, a protein tracer. This neuronal perturbation, observed without cellular damage, may represent a morphological correlate of the injury.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Pathology

    Background:

    • Concussive brain injury can cause physiological responses without apparent neuropathological changes.
    • Understanding the cellular mechanisms following mild traumatic brain injury is crucial.

    Purpose of the Study:

    • To investigate neuronal responses to concussive brain injury using horseradish peroxidase as a tracer.
    • To determine if neuronal changes occur without detectable subcellular alterations.

    Main Methods:

    • Light and electron microscopy were used to examine neuronal inundation with horseradish peroxidase.
    • Horseradish peroxidase was intravenously infused into animals following mechanical brain injury.

    Main Results:

    • Vascular peroxidase exudation and neuronal inundation occurred in the raphe and reticular core following concussive injury.

    Related Experiment Videos

  • Inundated neurons initially showed complete flooding, followed by peroxidase reorganization into vesicles and vacuoles.
  • Peroxidase was observed to reach the nucleus and nucleolus within 24 hours, without evidence of subcellular alteration.

    • Conclusions:

    • The observed neuronal inundation, reorganization, and nuclear uptake of peroxidase suggest a subtle, transient neuronal perturbation.
    • This perturbation may serve as a morphological correlate for concussive brain injury episodes.