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C cell carcinoma of the thyroid--papillary type.

K Kakudo, A Miyauchi, S Takai

    Acta Pathologica Japonica
    |July 1, 1979
    PubMed
    Summary

    Papillary C cell carcinoma of the thyroid exhibits distinct histologic features, including papillary structures and amyloid deposition. This study confirms the papillary type is a genuine variation, not an artifact.

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    Area of Science:

    • Endocrinology
    • Surgical Pathology
    • Oncology

    Background:

    • Medullary thyroid carcinoma (MTC) is a malignant tumor arising from C cells.
    • Histologic variants of MTC can present diagnostic challenges.
    • Understanding these variants is crucial for accurate diagnosis and patient management.

    Observation:

    • Two cases of papillary C cell carcinoma of the thyroid were analyzed.
    • Histologic examination revealed characteristic papillary structures with fibrovascular cores.
    • Positive histochemical staining for argyrophil reaction and stromal amyloid deposition were noted.

    Findings:

    • Ultrastructural analysis confirmed the presence of secretory granules within tumor cell cytoplasm.
    • The observed papillary architecture was consistent and reproducible in properly fixed tissues.
    • The findings support the papillary type as a distinct histologic variation of C cell carcinoma.

    Implications:

    • This research clarifies the nature of the papillary variant of C cell carcinoma.
    • Accurate identification of this variant can refine prognostication and treatment strategies.
    • It emphasizes the importance of meticulous histologic and ultrastructural evaluation in thyroid pathology.

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