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Reversed development and cellular aging in an insect.

S D Beck, R K Bharadwaj

    Science (New York, N.Y.)
    |December 15, 1972
    PubMed
    Summary
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    Larvae of Trogoderma glabrum beetles can reverse development when starved, shrinking and losing weight. Upon refeeding, they regrow, demonstrating remarkable developmental plasticity and resilience.

    Area of Science:

    • Developmental biology
    • Insect physiology
    • Entomology

    Background:

    • Larval development is typically unidirectional.
    • Environmental stress can impact insect development.
    • Trogoderma glabrum larvae exhibit unique responses to deprivation.

    Purpose of the Study:

    • To investigate the phenomenon of reversed development in Trogoderma glabrum larvae.
    • To understand the physiological consequences of repeated developmental reversals.
    • To explore the relationship between larval regression and aging indicators.

    Main Methods:

    • Larvae of Trogoderma glabrum were subjected to cycles of food and water deprivation and refeeding.
    • Measurements of larval size and weight were recorded.
    • Developmental stages and organ differentiation were observed.

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  • Physiological changes, including fat body polyploidy, were assessed.

    • Main Results:

    • Larvae underwent retrogressive larval ecdyses when deprived of resources, decreasing in size and weight.
    • Refed larvae successfully regrew, ecdyzed, and regained their previous maturity.
    • Repeated cycles of retrogression and regrowth were feasible.
    • Repeatedly retrogressed larvae showed physiological deterioration resembling aging, with declining regrowth ability and increasing fat body polyploidy.

    Conclusions:

    • Trogoderma glabrum larvae possess a capacity for partially reversed development in response to starvation.
    • This developmental plasticity is finite, as repeated cycles lead to physiological decline.
    • Increasing fat body polyploidy correlates with the deterioration of regrowth ability, suggesting a link to aging processes in insects.