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Detection of staphylococcal nuclease elaborated during lethal infections in mice
Infection and Immunity
|December 1, 1972
Abstract:
Active staphylococcal nuclease was detected in tissues of lethally infected mice. Organ distribution and levels of the enzyme varied with the bacterial strain used.
Insights
Active staphylococcal nuclease was found in mice with lethal Staphylococcus infections. The enzyme
Area of Science:
- Microbiology
- Immunology
- Toxicology
Background:
- Staphylococcus infections can cause severe disease.
- Staphylococcal nuclease is an enzyme produced by Staphylococcus bacteria.
Purpose of the Study:
- To investigate the presence and distribution of staphylococcal nuclease in tissues of mice with lethal infections.
- To determine if bacterial strain influences enzyme levels and organ distribution.
Main Methods:
- Mice were lethally infected with different strains of Staphylococcus.
- Tissues were analyzed for the presence and levels of staphylococcal nuclease.
Main Results:
- Active staphylococcal nuclease was detected in tissues of infected mice.
- The distribution and concentration of the enzyme varied depending on the specific Staphylococcus strain used for infection.
Conclusions:
- Staphylococcal nuclease is present in tissues during lethal Staphylococcus infections.
- Bacterial strain is a significant factor affecting staphylococcal nuclease levels and tissue distribution in vivo.
