Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible renal concentrating defect in shock.

R Whang, M Brandfonbrener

    Lancet (London, England)
    |February 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Renal concentrating ability lost during hemorrhagic shock (HS) is recoverable. HS impairs kidney function by reducing blood flow and altering ion transport, but fluid resuscitation restores concentrating power.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Magnesium and potassium supplementation in the prevention of diabetic vascular disease.

    Medical hypotheses·2000
    Same author

    Electrolyte & water metabolism in sports activities.

    Comprehensive therapy·1998
    Same author

    Clinical disorders of magnesium metabolism.

    Comprehensive therapy·1997
    Same author

    Significance of magnesium in congestive heart failure.

    American heart journal·1996
    Same author

    Metabolic correlates of theophylline therapy: a concentration-related phenomenon.

    The Annals of pharmacotherapy·1994
    Same author

    Intravenous magnesium therapy in acute myocardial infarction.

    The Annals of pharmacotherapy·1994
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Nephrology
    • Physiology
    • Pathophysiology

    Background:

    • Hemorrhagic shock (HS) significantly impairs renal function.
    • Loss of renal concentrating ability is a key consequence of HS-induced hypovolemia.

    Purpose of the Study:

    • To elucidate the sequential mechanisms underlying the loss of renal concentrating power during HS.
    • To identify the key factors involved in the reversibility of renal dysfunction after HS correction.

    Main Methods:

    • The study describes a sequence of physiological events following acute hypovolemia.
    • It details the impact on renal blood flow, nephron perfusion, and ion transport.
    • Mechanisms of medullary interstitial hypertonicity changes were analyzed.

    Main Results:

    Related Experiment Videos

    • HS reduces renal blood flow and superficial cortical nephron perfusion.
    • Juxtamedullary nephron perfusion continues, leading to enhanced proximal reabsorption.
    • This results in diminished medullary interstitial hypertonicity and reduced concentrating capacity, exacerbated by vasa recta washout.

    Conclusions:

    • The loss of renal concentrating power in HS is reversible upon correction of the shock state.
    • Restoration of blood volume normalizes renal medullary hypertonicity by adjusting ion delivery and perfusion dynamics.
    • Understanding these mechanisms is crucial for managing HS-related kidney injury.