Effect on reproductive organs of three clomiphene analogues

1. The oestrogenic properties of four triphenylethylene compounds were compared. They can be listed as follows in order of their oestrogenic potency: 1-[p-(beta-diethylaminoethoxy)-phenyl]-2-nitro-1,2-diphenylethylene (E.I.P.W. 111) > clomiphene > 1-[p-(beta-dimethylaminoethoxy)-phenyl]-2-nitro-1, 2-diphenylethylene (E.I.P.W. 113)> 1-[p-(beta-diethylaminoethoxy)-phenyl]-1,2-diphenylethylene (E.I.P.W. 103). The oestrogenic potency of compound E.I.P.W. 111 was found to be about 1/10th of that of oestradiol.2. Compound E.I.P.W. 111 is partially antioestrogenic but not progesteronic in nature. It has no androgenic effect.