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Percutaneous absorption in experimental epidermal disease.

A E Solomon, N J Lowe

    The British Journal of Dermatology
    |June 1, 1979
    PubMed
    Summary
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    Topical drug absorption is poorly understood in skin diseases with epidermal changes. This study shows increased hydrocortisone absorption in experimentally induced abnormal mouse skin, indicating a defective skin barrier.

    Area of Science:

    • Dermatology
    • Pharmacology
    • Skin Barrier Research

    Background:

    • Topical drug absorption in epidermal diseases with proliferation and keratinization defects is not well understood.
    • Experimental models are needed to investigate skin barrier function in disease states.

    Purpose of the Study:

    • To investigate the percutaneous absorption of topical drugs in experimentally induced epidermal disease.
    • To assess the integrity of the skin barrier in conditions of epidermal proliferation and altered keratinization.

    Main Methods:

    • Induction of abnormal hairless mouse epidermis using ultraviolet light, vitamin A acid, and acetic acid.
    • Measurement of epidermal thickness in induced and normal skin.
    • In vitro percutaneous absorption studies using 0.1% (4-14C) hydrocortisone.

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    Main Results:

    • Experimental induction resulted in increased epidermal thickness compared to normal controls.
    • In vitro percutaneous absorption of hydrocortisone was significantly increased in the abnormal epidermis.
    • These findings suggest a compromised skin barrier function in the experimental models.

    Conclusions:

    • Experimental epidermal disease models exhibit defective skin barrier function.
    • Increased epidermal thickness correlates with enhanced topical drug absorption.
    • This research provides evidence for impaired barrier function in specific epidermal disorders.