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The partial thromboplastin (cephalin) time test.

L Poller, J M Thomson

    Journal of Clinical Pathology
    |December 1, 1972
    PubMed
    Summary
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    Commercial cephalin reagents show significant variability in clotting tests for anticoagulant and hemophilia patients. Standardization is challenging, highlighting the need for reliable, sensitive reagents for accurate clinical monitoring.

    Area of Science:

    • Hematology
    • Clinical Chemistry
    • Biotechnology

    Background:

    • Partial thromboplastin (cephalin) reagents are crucial for monitoring coagulation.
    • Standardization of cephalin reagents is essential for reliable clinical diagnostics.

    Purpose of the Study:

    • To compare the performance of nine partial thromboplastin (cephalin) reagents.
    • To evaluate reagent suitability for patients on anticoagulants, with hemophilia, and on heparin infusion.
    • To assess the utility of a standardized reference preparation for quality control.

    Main Methods:

    • Comparative analysis of seven commercial cephalin reagents and two human extracts.
    • Correlation of results with a standardized human brain-derived cephalin preparation.
    • Evaluation of reagent performance across patient groups with varying coagulation statuses.

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    Main Results:

    • Significant variability in results across all tested cephalin reagents and patient groups.
    • Some commercial reagents demonstrated insensitivity to intrinsic clotting defects in oral anticoagulant users.
    • Poor endpoint definition limited the dependability of most reagents, especially in hemophilia and heparin monitoring.

    Conclusions:

    • Current commercial cephalin reagents lack standardization and exhibit poor performance.
    • A standardized reference cephalin material showed limited promise for routine quality control.
    • There is a critical need for standardized, sensitive cephalin reagents with reproducible endpoints for clinical use.