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Related Experiment Videos

[Placental metastasis (author's transl)].

A Demaille, P Cappelaere

    Bulletin Du Cancer
    |January 1, 1979
    PubMed
    Summary

    Maternal cancer rarely metastasizes to the placenta or fetus. True placental metastases are exceptional, and fetal protection against maternal cancer is generally observed.

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    An EORTC-ECSG phase II study of vinorelbine in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.

    Annals of oncology : official journal of the European Society for Medical Oncology·1998

    Area of Science:

    • Obstetrics and Gynecology
    • Oncology
    • Pathology

    Context:

    • Placental metastasis from maternal cancer is infrequently diagnosed due to limited histological examination of placentas from affected mothers.
    • Tumor emboli can lodge in the intervillous spaces, mimicking metastasis without true invasion.

    Purpose:

    • To review the incidence and characteristics of true placental metastases and fetal involvement from maternal malignancies.
    • To clarify the risk of transplacental cancer spread to the fetus and its implications for pregnancy management.

    Summary:

    • True placental metastases are rare, with only twelve cases reported, predominantly malignant melanomas.
    • Fetal metastasis is exceptionally rare, indicating the fetus is generally protected from maternal cancer.
    • Maternal cancer is not a valid reason for pregnancy termination due to the low risk of fetal metastasis.

    Impact:

    • Provides clarity on the low risk of fetal metastasis from maternal cancer, informing clinical decisions regarding pregnancy management.
    • Highlights the rarity of placental and fetal involvement in maternal cancer, reassuring patients and clinicians.

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