Related Experiment Video

Updated: Aug 10, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

The excretion of alkaline ribonuclease by children undergoing surgery

G B Barlow, S H Whitear, A W Wilkinson

    The British Journal of Surgery
    |June 1, 1979
    PubMed

    Insights

    Alkaline ribonuclease excretion increased in children after major heart or intestinal surgery. This elevation suggests potential pancreatic function disturbances in pediatric patients post-operation.

    Area of Science:

    • Biochemistry
    • Pediatric Surgery
    • Clinical Chemistry

    Background:

    • Assessing post-operative physiological changes is crucial in pediatric care.
    • Alkaline ribonuclease (RNase) is an enzyme with potential roles in cellular processes.

    Observation:

    • Urine samples were collected from pediatric patients undergoing major surgical procedures.
    • Alkaline ribonuclease excretion levels were measured in these samples.

    Findings:

    • Significantly increased alkaline ribonuclease excretion was observed in children post-open heart surgery.
    • Elevated levels were also noted in many infants operated on for intestinal anomalies shortly after birth.

    Implications:

    • The observed elevations in urinary alkaline ribonuclease may serve as a biomarker for post-surgical stress.
    • These findings suggest a potential disturbance in pancreatic function following major pediatric operations, warranting further investigation.

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