Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal function after long-term treatment with lithium.

R P Hullin, V P Coley, N J Birch

    British Medical Journal
    |June 2, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Two Cases of Pyrexia from <i>B. Columbensis</i>.

    The Indian medical gazette·2017
    Same author

    Dormancy-release of celery seed by a growth retardant, N-dimethylaminosuccinamic acid (alar).

    Planta·2014
    Same author

    A modified Amaranthus betacyanin bioassay for the rapid determination of cytokinins in plant extracts.

    Planta·2014
    Same author

    THE PHOBIA AS THE FUNDAMENTAL FACTOR IN THE PSYCHONEUROSIS.

    The Journal of neurology and psychopathology·2011
    Same author

    Recovery of cellular activity in cryopreserved human foetal brain tissue.

    Restorative neurology and neuroscience·2011
    Same author

    Use of large daily injections of penicillin emulsion in dermatology.

    Missouri medicine·2010
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Long-term lithium treatment for affective disorders does not significantly impair renal function. Patients showed normal creatinine clearance and tubular function, with reduced arginine vasopressin (AVP) responsiveness.

    Area of Science:

    • Nephrology
    • Psychiatry
    • Pharmacology

    Background:

    • Lithium is a common treatment for bipolar and unipolar affective disorders.
    • Concerns exist regarding potential long-term renal impairment from lithium therapy.
    • Previous studies have suggested lithium may cause renal damage and polyuria.

    Purpose of the Study:

    • To assess renal function in patients treated with lithium.
    • To compare renal function between lithium-treated patients and those on other psychotropic drugs.
    • To investigate the effect of lithium on arginine vasopressin (AVP) responsiveness.

    Main Methods:

    • Measured daily urine volumes, plasma creatinine, and creatinine clearance in 106 patients.
    • Assessed renal tubular function, including response to water deprivation, in 30 lithium patients and 30 controls.

    Related Experiment Videos

  • Measured urinary arginine vasopressin (AVP) excretion.

    • Main Results:

    • Most patients had normal urine volumes, plasma creatinine, and creatinine clearance.
    • No significant differences in creatinine clearance or tubular function were found between lithium and control groups.
    • Lithium-treated patients had higher urinary AVP excretion and diminished tubular responsiveness to AVP.

    Conclusions:

    • Long-term lithium treatment does not appear to cause serious renal impairment or damage.
    • Reduced tubular responsiveness to AVP in lithium patients does not lead to significant functional deficits.
    • Low serum lithium concentrations may be effective for prophylaxis and potentially safer for renal function.