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Related Experiment Videos

Low-level, progestogen-releasing vaginal contraceptive devices.

F G Burton, W E Skiens, G W Duncan

    Contraception
    |May 1, 1979
    PubMed
    Summary

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    New vaginal contraceptive devices using silicone rubber effectively inhibit sperm penetration. Most formulations allowed ovulation, except for high-dose norethindrone devices, indicating potential for controlled female contraception.

    Area of Science:

    • Reproductive Health
    • Contraceptive Technology
    • Materials Science

    Background:

    • Development of novel drug delivery systems for contraception is crucial.
    • Controlled release of progestogens offers potential for effective and user-friendly birth control.

    Purpose of the Study:

    • To design, fabricate, and evaluate silicone rubber vaginal contraceptive devices.
    • To assess the in vivo release rates and contraceptive efficacy of different progestogen formulations.

    Main Methods:

    • Fabrication of four silicone rubber vaginal device formulations.
    • Testing in 90-day clinical trials with 70 devices.
    • Measurement of in vivo release rates of progesterone, norethindrone, and d-norgestrel.
    • Evaluation of cervical sperm penetration and ovulation status.
    Keywords:
    BiologyClinical ResearchContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Progestin--administraction and dosageContraceptive Agents--administraction and dosageContraceptive MethodsContraceptive Mode Of ActionEndocrine SystemFamily PlanningHormonesInhibition Of FertilizationIudIud, Hormone ReleasingLevonorgestrel--administraction and dosageNorethindrone--administraction and dosageOral ContraceptivesPhysiologyProgestational HormonesProgesterone--administraction and dosageResearch MethodologySperm Transport Inhibition

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    Main Results:

    • In vivo release rates varied by formulation: progesterone (1400 ± 30 µg/day), norethindrone (49.4 ± 2.4 and 196 ± 21 µg/day), and d-norgestrel (21.6 ± 1.4 µg/day).
    • All four formulations inhibited sperm penetration of the cervix.
    • Ovulation occurred in most women, except for those using high-dose norethindrone devices.
    • Norgestrel-releasing devices showed the most consistent inhibition of sperm penetration.

    Conclusions:

    • Silicone rubber vaginal devices can be fabricated to release controlled doses of progestogens.
    • These devices demonstrate potential as a contraceptive method by inhibiting sperm penetration.
    • Further research may optimize formulations for consistent ovulation suppression and enhanced contraceptive efficacy.