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Effects of human chorionic gonadotropin preparations on complement in vitro
The effects on complement in vitro by several commercial preparation of human chorionic gonadotropin (HCG) were investigated. These preparations were demonstrably anticomplementary and produced marked conversion of the third component of complement (C'3). However, detailed analyses showed that the anticomplementary activity was because of the presence of immunoglobulins in the HCG preparations. In view of the known modifying effects of C'3-reactive agents on skin allograft survival and of antigen-antibody complexes on lymphocyte transformation, it may be necessary to reconsider previous work on the immunosuppressive effects of HCG preparations.
The effects on complement in vitro by several commercial preparation of human chorionic gonadotropin (HCG) were investigated. These preparations were demonstrably anticomplementary and produced marked conversion of the third component of complement (C'3). However, detailed analyses showed that the anticomplementary activity was because of the presence of immunoglobulins in the HCG preparations. In view of the known modifying effects of C'3-reactive agents on skin allograft survival and of antigen-antibody complexes on lymphocyte transformation, it may be necessary to reconsider previous work on the immunosuppressive effects of HCG preparations.