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Does motilin regulate canine interdigestive gastric motility?

P A Thomas, K A Kelly, V L Go

Digestive Diseases and Sciences

|August 1, 1979

Summary

This summary is machine-generated.

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Motilin significantly increases the frequency of cyclic interdigestive motor activity in the canine stomach. This effect on gastric motility occurs independently of extrinsic nerve supply.

Area of Science:

Gastroenterology
Physiology

Background:

Interdigestive motor activity is crucial for gastrointestinal motility.
Motilin is a hormone implicated in regulating gut functions.

Purpose of the Study:

To investigate the effect of motilin on the frequency of cyclic interdigestive motor activity in the canine proximal stomach.
To determine if motilin influences the timing between gastric pouch and duodenal cycles.

Main Methods:

Utilized 4 conscious dogs with autotransplanted proximal gastric pouches and gastrointestinal electrodes.
Administered intravenous infusions of motilin (0.6 microgram/kg/hr) and analyzed plasma motilin concentrations.
Monitored and recorded cyclic interdigestive motor activity in the stomach and duodenum.

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Main Results:

Intravenous motilin infusion increased the frequency of interdigestive cycles by 30% in both the gastric pouch and main gastrointestinal tract.
The interval between cycle completion in the pouch and duodenum remained unaffected by motilin.
Endogenous and exogenous motilin levels were significantly higher during the contractile phase compared to the quiescent phase of cycles.

Conclusions:

Motilin administration enhances the frequency of cyclic interdigestive motor activity in the canine proximal stomach.
The observed increase in motor activity frequency is independent of the proximal gastric extrinsic innervation.