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Related Experiment Videos

Amphetamine and conditioned 'anxiety'.

H Cappell, R Ginsberg, C D Webster

    British Journal of Pharmacology
    |July 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    (+)-Amphetamine sulphate reduced both baseline responding and conditioned suppression in rats. This suggests caution when using conditioned suppression as an animal model for anxiety in psychopharmacology.

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    Area of Science:

    • Neuroscience
    • Psychopharmacology
    • Behavioral Science

    Background:

    • Rats exhibit baseline responding for rewards, which is suppressed by stimuli predicting aversive events (conditioned suppression).
    • Understanding how drugs affect this suppression is crucial for behavioral science and psychopharmacology.

    Purpose of the Study:

    • To investigate the effects of (+)-amphetamine sulphate on conditioned suppression in a rat model.
    • To determine if amphetamine alters baseline responding and the suppression induced by an aversive stimulus.

    Main Methods:

    • Rats were trained to press a bar for milk reward.
    • An auditory stimulus paired with electric shock was introduced to induce conditioned suppression.
    • (+)-Amphetamine sulphate was administered at doses of 0.5, 1.0, and 2.0 mg/kg.

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    Main Results:

    • (+)-Amphetamine sulphate dose-dependently reduced baseline responding.
    • (+)-Amphetamine sulphate also dose-dependently reduced conditioned suppression, partially restoring responding during the auditory stimulus.
    • The drug attenuated suppression regardless of its initial degree.

    Conclusions:

    • (+)-Amphetamine sulphate attenuates conditioned suppression in rats, contrary to some previous findings.
    • The conditioned suppression procedure should be used cautiously as an animal model of anxiety in psychopharmacological research.
    • Findings highlight the complex effects of amphetamine on fear-related behaviors.