[Comparison of the decurarizing and median lethal doses of 2-aminopyridine salts]

The authors determined LD50 of 2-aminopyridine hydrochloride, 2-aminopyridine jodmethylate, 2-aminopyridine methyl-para-toluolsulfonat and pymadine (4-aminopyridine hydrochloride) in mice and rats after subcutaneous administration. They found that doses of the same compounds during indirect stimulation of m. gastrocknemius removed myorelaxating action of (+)-tubocurarine. LD50 and decurarizing doses of jodmethylates and methyl-para-toluosulfonat were higher than LD50 of hydrochloride of 2-aminopyridine. When LD50 was compared with the decurarizing dose of 2-aminopyridine methyl-para-toluolslufonat, its lower toxicity and potential perspectivity for practical application as an anticurare agent was indicated.