Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteomalacic myopathy.

S Yoshikawa, T Nakamura, H Tanabe

    Endocrinologia Japonica
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Osteomalacia causes distinct muscle damage, including fiber atrophy and network disruption, termed osteomalacic myopathy. Phosphate depletion and reduced vitamin D effects are key contributing factors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Urinary titin as a biomarker of sarcopenia in diabetes: a propensity score matching analysis.

    Journal of endocrinological investigation·2024
    Same author

    Rapid effects of dupilumab treatment on papuloerythroderma of Ofuji.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Subcutaneous pseudocystic phaeohyphomycosis due to Exophiala jeanselmei mimicking an epidermal cyst.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Pemphigus vulgaris in a recipient and pemphigus foliaceus in a donor after allogeneic peripheral blood stem cell transplantation between two siblings.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Gli2 protein expression level is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.

    Polish journal of pathology : official journal of the Polish Society of Pathologists·2016
    Same author

    Electron and Ion Heating Characteristics during Magnetic Reconnection in the MAST Spherical Tokamak.

    Physical review letters·2015
    Same journal

    Anti-eye muscle antibodies and hypothyroid Graves' disease: a case report.

    Endocrinologia japonica·1992
    Same journal

    No inhibitory effects of gestrinone and medroxyprogesterone acetate on the estrogen production by ovaries of hypophysectomized rats stimulated by gonadotropins.

    Endocrinologia japonica·1992
    Same journal

    Immunohistochemical evidence that rat FSH cells contain beta II-subspecies of protein kinase C.

    Endocrinologia japonica·1992
    Same journal

    Source of prolactin in human follicular fluid.

    Endocrinologia japonica·1992
    Same journal

    Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its family.

    Endocrinologia japonica·1992
    Same journal

    Transient extreme insulin resistance in shock during diabetic ketoacidosis.

    Endocrinologia japonica·1992
    See all related articles

    Area of Science:

    • Neurology
    • Pathology
    • Biochemistry

    Background:

    • Osteomalacia, a bone disease, can affect muscle function.
    • Understanding the specific muscle pathology in osteomalacia is crucial.

    Observation:

    • Histochemical and electron microscopy revealed distinct muscle changes in two osteomalacia patients.
    • Common findings included scattered muscle fiber atrophy, necrosis, internal nuclei, and type II fiber atrophy.
    • Intermyofibrillar network derangement was also observed.

    Findings:

    • Electron microscopy confirmed light microscopy findings, supporting unique pathological features.
    • These distinct features warrant the classification of 'osteomalacic myopathy'.
    • Key pathogenetic mechanisms involve phosphate depletion affecting muscle glycolysis and reduced vitamin D impacting calcium uptake.

    Related Experiment Videos

    Implications:

    • Identifies specific muscle pathology associated with osteomalacia.
    • Highlights the role of phosphate and vitamin D in muscle function.
    • Provides a basis for further research into osteomalacic myopathy treatment.