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Related Experiment Videos

Myelin membrane structure as revealed by x-ray diffraction.

D Harker

    Biophysical Journal
    |October 1, 1972
    PubMed
    Summary
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    This study reinterprets X-ray diffraction data of myelin membrane structure. A new electron density model provides quantitative agreement with experimental data, refining our understanding of myelin

    Area of Science:

    • Biophysics
    • Structural Biology
    • X-ray Crystallography

    Background:

    • Myelin membrane structure is crucial for nerve impulse conduction.
    • Previous X-ray diffraction studies provided data on myelin structure.
    • Interpreting electron density projections from diffraction data can be ambiguous.

    Purpose of the Study:

    • To propose a new interpretation of existing X-ray diffraction data for myelin membrane.
    • To present an alternative electron density model for the myelin multilayer.
    • To achieve quantitative agreement with experimental X-ray diffraction data.

    Main Methods:

    • Re-analysis of X-ray diffraction data from Akers and Parsons (1970).
    • Calculation of Fourier series coefficients for electron density projections.

    Related Experiment Videos

  • Development of a new structural model for the myelin double layer.

    • Main Results:

    • An alternative electron density function, or its negative, is consistent with the data.
    • A specific sequence of signs (+ - - + + or - + + - -) was determined for the Fourier coefficients.
    • A refined myelin model features a 171 Å double layer with specific lipid and protein layer thicknesses.

    Conclusions:

    • The proposed model offers a better fit to the experimental X-ray diffraction data than previous interpretations.
    • The new model details the arrangement and dimensions of lipid and protein layers within the myelin structure.
    • Further refinements may be needed for higher-order reflection data.