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Infectious antibody-reovirus complexes.

D O Huggett, J E Rodríguez, A P McKee

    Infection and Immunity
    |December 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Reovirus type 1 neutralization resistance was investigated. Residual infectious fractions were identified as infectious antibody-virion complexes, not distinct virus particles.

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    Area of Science:

    • Virology
    • Immunology
    • Biochemistry

    Background:

    • Reovirus type 1 exhibits incomplete neutralization by specific antiviral serum.
    • The mechanism behind this incomplete neutralization requires elucidation.

    Purpose of the Study:

    • To investigate the nature of the residual infectious fraction of reovirus type 1 after exposure to neutralizing antibody.
    • To determine if morphologically or density-distinct virus particles contribute to incomplete neutralization.

    Main Methods:

    • Equilibrium zonal density gradient centrifugation to separate virus particles and complexes.
    • Electron microscopy to analyze virus particle morphology.
    • Incubation of reovirus with specific antiviral serum and anti-rabbit serum.

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    Main Results:

    • The residual infectious fraction was identified as infectious antibody-virion complexes.
    • Electron microscopy showed three morphologically distinct virus particle classes.
    • Density gradient centrifugation revealed only one infectious peak, consisting of antibody-virion complexes.

    Conclusions:

    • Incomplete neutralization of reovirus type 1 is due to the formation of infectious antibody-virion complexes.
    • These complexes do not arise from pre-existing morphologically or density-distinct virus populations.