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The APUD cell concept.

L H Smith

    Journal of Surgical Oncology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Embryonic neural crest cells differentiate into amine precursor uptake and decarboxylation (APUD) cells, which produce hormones. This concept links endocrine gland function and tumor hormone production.

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    Area of Science:

    • Developmental biology
    • Endocrinology
    • Cell biology

    Background:

    • Embryonic neural crest cells are a migratory cell population with diverse differentiation potential.
    • The amine precursor uptake and decarboxylation (APUD) cell system comprises various endocrine and neuroendocrine cells.

    Purpose of the Study:

    • To trace the developmental origin of APUD cells.
    • To elucidate the role of APUD cells in endocrine function and tumor biology.

    Main Methods:

    • Cell lineage tracing studies in embryonic development.
    • Immunohistochemical analysis of APUD cell markers.
    • Analysis of hormone production in endocrine tissues and tumors.

    Main Results:

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  • Embryonic neural crest cells were identified as the precursors of APUD cells.
  • APUD cells were found to originate from the primitive entoderm.
  • The APUD cell concept provides a unifying explanation for diverse clinical conditions.

    • Conclusions:

    • Neural crest cells differentiate into APUD cells, contributing to the endocrine system.
    • The APUD cell concept is crucial for understanding endocrine gland physiology and pathology.
    • This developmental insight aids in diagnosing and managing hormone-related tumors.