Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Copper-induced heart malformations in hamsters.

F J DiCarlo

    Experientia
    |June 15, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Copper citrate injections in pregnant hamsters caused specific birth defects in embryos. These included double-outlet right ventricle, pulmonary hypoplasia, and ventricular septal defects, highlighting copper

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): evidence for heterogeneity.

    Hepatology (Baltimore, Md.)·1997
    Same author

    Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS.

    The New England journal of medicine·1995
    Same author

    Disseminated leiomyosarcoma in a child with acquired immune deficiency syndrome.

    Cancer·1991
    Same author

    Neoplastic diseases in children with acquired immunodeficiency syndrome.

    Progress in AIDS pathology·1990
    Same author

    Rheumatic heart disease in a patient with acquired immunodeficiency syndrome.

    Human pathology·1989
    Same author

    Sarcoidosis of the uterus.

    Archives of pathology & laboratory medicine·1989

    Area of Science:

    • Teratology
    • Developmental Biology
    • Cardiovascular Science

    Background:

    • Congenital heart defects (CHDs) are a significant cause of infant mortality.
    • Understanding the teratogenic effects of environmental factors is crucial for preventing CHDs.

    Purpose of the Study:

    • To investigate the specific cardiovascular malformations induced by copper citrate exposure during pregnancy in a golden hamster model.

    Main Methods:

    • Pregnant golden hamsters were administered copper citrate.
    • Embryos were examined for the presence and type of cardiovascular malformations.

    Main Results:

    • Copper citrate exposure resulted in a distinct pattern of cardiovascular malformations.
    • The observed syndrome included double-outlet right ventricle, pulmonary hypoplasia, and ventricular septal defects.

    Related Experiment Videos

    Conclusions:

    • Copper citrate acts as a teratogen, inducing specific CHDs in developing embryos.
    • This model provides insights into the mechanisms of copper-induced cardiovascular teratogenesis.