Therapeutic donor insemination: results and causes of nonfertilization

The results of therapeutic donor insemination (AID) in 108 women are presented. Of the 108 women, 65 (60%) achieved a pregnancy. Eighty-five per cent of the pregnancies occurred with six AIDs or less, and 80% resulted in live births. The reasons why 43 women did not conceive are analyzed. The most common cause of failure was discontinuing the AID program. Of the original 108 women, 34 (32%) had dropped out of the program by the time they had received 6 AIDs or less. Reproductive abnormalities in the wife, and irregular ovulatory patterns, were the next most common causes of failure, and were often associated with discontinuation of the program. Advice regarding 2 days of sexual abstinence prior to AID was considered to improve the pregnancy rate. Fresh semen was shown to be superior to frozen samples in achieving pregnancies.