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Related Experiment Videos

Congenital varicella associated with multiple defects.

J B McKendry, J D Bailey

    Canadian Medical Association Journal
    |January 6, 1973
    PubMed
    Summary

    Maternal varicella infection during early pregnancy can lead to severe congenital defects in newborns. This case highlights the importance of considering maternal viral infections in diagnosing birth defects.

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    Area of Science:

    • Pediatrics
    • Obstetrics
    • Virology

    Background:

    • Congenital defects can arise from various factors, including maternal infections.
    • Varicella (chickenpox) during the first trimester of pregnancy is rarely associated with congenital malformations.

    Purpose of the Study:

    • To report a case of a neonate with multiple congenital defects following maternal varicella in early pregnancy.
    • To emphasize the need for investigating maternal infections in cases of unexplained congenital anomalies.

    Main Methods:

    • Case report of a female infant born to a mother with varicella at 11 weeks gestation.
    • Clinical and radiological investigations of the infant's developmental abnormalities.

    Main Results:

    • The infant presented with prematurity, intrauterine growth restriction, skin and muscular defects, respiratory distress, and developmental delay.
    • Further findings included unilateral diaphragmatic weakness, scoliosis, ocular fundi abnormalities, and seizures.
    • Autopsy revealed dilated ventricles, and the infant died at 20 months.

    Conclusions:

    • Maternal varicella in the first trimester can result in significant congenital malformations.
    • Investigating maternal viral infections and performing antibody studies in newborns and mothers is crucial for diagnosing congenital defects.

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